Ideas For Your Internet Marketing Campaign - Maynas Eric

Do you have a great business idea? With the internet developing a business based on an idea, it has never been easier. If you require some assistance, use this advice.

Integrate social media outlets like Facebook and Twitter into your Online marketing efforts. This helps to interact with your visitors and provide them updates as well. Although, you should not advertise too often as this can push your customers away. Try to keep your posts valuable and insightful, and only include marketing in a portion of them.

Consider implementing a banner in your site with your business logo or mission statement. This will help make your site more recognizable and help your customers know what you and your website are all about. Make it easy for customers to order products and services.

TIP! A short-term sales promotion can quickly improve your website?s PageRank. If the deal you offer is good enough, consumer deals sites will offer links to your website.

A sense of security is important to many online shoppers. Make your customers feel secure that they can feel perfectly safe entering their personal information on your website. Put a site-wide link to your privacy policy at the top right corner of your site. That way, customers who are worried about identity theft will have something to have their fears allayed. Furthermore, you have an obligation to protect your customers from fraud.

Part of operating a successful online business is ongoing market research on your competitors. Peruse your competitors? websites, noting what they could be doing better. Look through the websites of your competition. If you see that they are lacking in services that you offer, boast this in your advertising copy.

Make sure you use emphasis tools when you develop text on your website. Aim to emphasize important words by bolding, underlining, or italicizing them. You can get your point across if you find out how your customers like being communicated with.

TIP! Be sure to have at least one very unique characteristic or offering on your website. This will most likely get you a ton of traffic.

Consider making a video demonstration of the products you?re selling. You can allow the customer to see you with the product this way. Use this platform to fully outline features and benefits of your product that can be missed in the advertising. Post your video on your blog, as well as other websites like Vimeo and Youtube.

Try to avoid spending too much on advertising. You don?t want to spend any money on advertising that won?t help out your business. You should get the proper feedback and analysis of your online advertisements and break them down in terms of cost versus benefit. When the ratio gets unacceptable, it?s time to re-tool your marketing strategy.

Consider how good your product or service actually is. If your product is sub-par, no amount of Affiliate marketing will change that. If your product is the greatest ever, people will flock to it.

TIP! Consider blogging on a regular basis as a means to improve your internet marketing venture. Consistent blogging provides yet another way to keep your customers informed.

Be creative when designing your banner and avoid making ads that look generic. An exciting or interesting banner ad will attract more attention and inspire more clicks.

Incorporate a ?chat? option within your company website so that visitors can exchange information and interact together. People will identify with your brand if they can discuss things they enjoy with people who have similar interests. People enjoy being part of groups and clubs so treating them as if they are part of a select group will keep them coming back to your site.

Inspire confidence in your products by offering a guarantee that you will return a customer?s money if they are not satisfied. People don?t have a lot of money to spend these days, and trusting things bought online is hard enough as is. Offering a guarantee increase the sense of security a customer feels. When you give reassurance to your customers, they will be that much more likely to give you business.

TIP! Connect to other articles you have created by linking to them in your article. Keep your viewers on your site by giving them links to other informational content you have on your site.

Be sure to include photographs and other graphics that highlight the good qualities and uses of your product or service. Your customers will appreciate being able to clearly see the items that you are offering in detail, if they are considering placing an order. Considering including a section that allows customers to upload their own photos of your product. If you are selling a product for the improvements it makes, ?before and after? pictures can really help market the product.

Your goal is to build a solid business that will last and grow. The best measure of success is repeated success, and that is true of small businesses and big businesses alike. The tips listed here should help you build a solid online marketing company.

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Chinese astronaut teaches 60 million kids from space

A Chinese astronaut gave China its first physics lesson by video from space today, a required lesson for middle schools across the country.

By Peter Ford,?Staff writer / June 20, 2013

A student looks at his iPad as his class watches a live broadcast of a lecture given by Shenzhou-10 spacecraft astronauts on the Tiangong-1 space module, at a primary school in Quzhou, Zhejiang province June 20, 2013.

REUTERS

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It adds a whole new meaning to ?distance learning.?

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Beijing Bureau Chief

Peter Ford is The Christian Science Monitor?s Beijing Bureau Chief. He covers news and features throughout China and also makes reporting trips to Japan and the Korean peninsula.

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Chinese astronaut Wang Yaping gave a physics lesson by video from a space module orbiting more than 300 km (186 miles) above the earth?on Thursday.

She gulped a globule of water floating in the air, and pushed a fellow astronaut against the module?s wall with a touch of her finger, to illustrate the effects of weightlessness. Then she answered questions from a group of children gathered in a studio in Beijing watching the lesson on live TV.

The scene resembled a similar lesson that US elementary school teacher Barbara Morgan taught from the International Space Station in 2007. But this one had specifically Chinese characteristics.

The questions that the Chinese kids asked?on Thursday?were much like the questions that American kids asked six years ago. Do stars twinkle when you are in space? (No, because there is no atmospheric interference.) Have you seen any UFO?s? (?Not yet? was Ms. Wang?s answer to that one.)

But while Barbara Morgan and her colleagues participated in three low-key sessions with small groups of students in Idaho, Virginia, and Massachusetts, Wang?s class was broadcast nationwide on state TV?s premier channel and 60 million schoolchildren and teachers in 80,000 middle schools watched, according to China?s Education Ministry.

The ministry had ?issued instructions requiring middle schools to adjust their class schedules and organize students to watch? the lesson, according to its website.

The compulsory class reflected the importance that the Chinese government has attached to its ambitious space program. Beijing first sent a human into space only 10 years ago, but plans to build its own space station by 2020.

Beijing has more than just a technological interest in space. A few years ago, just before China launched its first lunar probe, the chief scientist for China's moon program, Ouyang Ziyuan, was blunt about its political purposes.

"Lunar exploration is a reflection of a country's comprehensive national power,? he said in an interview with the official newspaper People's Daily. ?It is significant for raising our international prestige and increasing our people's cohesion."

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/-r4oyi0Jidw/Chinese-astronaut-teaches-60-million-kids-from-space

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Taliban vow suicide and 'insider' attacks in new spring offensive

KABUL (Reuters) - The Taliban in Afghanistan vowed on Saturday to start a new campaign of mass suicide attacks on foreign military bases and diplomatic areas, as well as damaging "insider attacks", as part of a new spring offensive this year.

The offensive was announced via emails from Taliban spokesmen. The Islamist group has made similar announcements in recent years, which have sometimes been followed by spikes in violence after Afghanistan's harsh winter months.

The announcement of more mass suicide and insider attacks will likely be greeted with concern by the NATO-led military coalition, which is in the final stages of a fight against the Taliban-led insurgency that began in late 2001.

However, there was no immediate reaction to the Taliban's statement from the NATO-led International Security Assistance Force (ISAF).

After announcing their spring offensive last year, the Taliban launched a large attack in Kabul involving suicide bombers and an 18-hour firefight targeting Western embassies, ISAF headquarters and the Afghan parliament.

The start of the traditional "fighting season" is particularly important this year, with ISAF increasing the rate at which it hands security responsibility to Afghan forces before the withdrawal of most foreign troops by the end of 2014.

The Taliban statement said this year's offensive, named after Khalid bin Waleed, one of the companions of the Islamic prophet Mohammad, will involve "special military tactics" similar to those carried out previously.

"Collective martyrdom operations on bases of foreign invaders, their diplomatic centers and military airbases will be even further structured while every possible tactic will be utilized in order to detain or inflict heavy casualties on the foreign transgressors," the statement said.

Insider attacks, also known as "green on blue" attacks, involve Afghan police or soldiers turning their guns on their ISAF trainers and counterparts. They have grown considerably since last year and have strained relations between Kabul and foreign forces.

However, there is considerable debate over how many can be attributed to infiltration by insurgents and how many are by disgruntled members of the Afghan security forces.

Last August, then ISAF commander, U.S. General John Allen, said about a quarter of such attacks involved the Taliban.

The spring offensive was coordinated to begin on May 28 - or the 8th of the Islamic month of Thaur - to coincide with a national holiday to mark the overthrow of the Soviet-backed government of Mohammad Najibullah in 1992, the statement said.

(Reporting by Dylan Welch and Mirwais Harooni; Editing by Paul Tait)

Source: http://news.yahoo.com/taliban-vow-suicide-insider-attacks-spring-offensive-071938216.html

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Boeing says new battery system ensures 787 safety

Boeing Co.'s chief engineer Michael Sinnett speaks during a press conference on Boeing 787 jets in Tokyo, Saturday, April 27, 2013. Sinnett said Saturday that changes to the lithium-ion battery system are fully sufficient to ensure the aircraft's safety, although the company has been unable to find the cause of the original battery failures earlier this year that led to groundings of the plane worldwide since mid-January. (AP Photo/Itsuo Inouye)

Boeing Co.'s chief engineer Michael Sinnett speaks during a press conference on Boeing 787 jets in Tokyo, Saturday, April 27, 2013. Sinnett said Saturday that changes to the lithium-ion battery system are fully sufficient to ensure the aircraft's safety, although the company has been unable to find the cause of the original battery failures earlier this year that led to groundings of the plane worldwide since mid-January. (AP Photo/Itsuo Inouye)

Boeing Co.'s chief engineer Michael Sinnett speaks during a press conference on Boeing 787 jets in Tokyo, Saturday, April 27, 2013. Sinnett said Saturday that changes to the lithium-ion battery system are fully sufficient to ensure the aircraft's safety, although the company has been unable to find the cause of the original battery failures earlier this year that led to groundings of the plane worldwide since mid-January. (AP Photo/Itsuo Inouye)

TOKYO (AP) ? Boeing Co.'s chief engineer for the 787 Dreamliner said Saturday that changes to the lithium-ion battery system are fully sufficient to ensure the aircraft's safety, although the company has been unable to find the cause of the original battery failures earlier this year that led to groundings of the plane worldwide since mid-January.

Michael Sinnett gave a briefing on the revamped battery to reporters in Tokyo after Japanese and U.S. regulators gave carriers permission to resume 787 flights once battery modifications are made.

The new battery system is designed to prevent a fire, and to contain one should it occur with an "enclosure," a casing around the battery to prevent heat from being released in the aircraft, Sinnett told a news conference in Tokyo.

"Even if we never know root cause, the enclosure keeps the airplane safe, it eliminates the possibility of fire, it keeps heat out of the airplane, it keeps smoke out of the airplane, and it ensures that no matter what happens to the battery, regardless of root cause, the airplane is safe," he said, adding "in some ways it almost doesn't matter what the root cause was."

He said Boeing has identified over 80 potential causal factors and addressed all of them in the new design.

The 50 Dreamliner jets in service worldwide were grounded in mid-January after incidents with smoldering batteries occurred aboard two different planes, leading to hundreds of cancelled flights and revenue losses.

Japan's two biggest carriers have the most 787s ? All Nippon Airways owns 17 of the jets, while Japan Airlines has seven. They have begun installing the new batteries over the last week, and airline officials said commercial flights would resume around June as the safety improvements are expected to take several weeks to finish.

It takes five days to completely retrofit one airplane, Sinnett said, and repairs to nine jets are almost complete. New batteries are being shipped from Japanese battery maker GS Yuasa to the airlines, he said.

ANA is planning to conduct a test flight using a modified Dreamliner in Japan on Sunday.

The only U.S. airline using the 787 is United Airlines, which owns six.

Japan is mandating additional safety measures including one test flight after the new system is installed. Operators will need to monitor the new battery system during flight and authorities will require airlines to conduct a detailed sampling inspection of the batteries after a certain period of use.

Special training for all on board personnel including the pilot on 787s is mandated, and airlines are to disclose information on safety measures taken on the 787 to the public.

Boeing has 840 purchase orders of the plane so far.

Sinnett declined to comment on cost for repairs worldwide. He plans to meet with executives from ANA and JAL during his Japan trip.

___

Associated Press writer Emily Wang contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-04-27-Japan-Boeing%20787/id-f827539ea5204be9a3563f46ed79f5ec

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Earth's cooling came to sudden halt in 1900, study shows

An international study used tree rings and pollen to build the first?record of global climate change, continent by continent, over 2,000 years.

By Pete Spotts,?Staff writer / April 23, 2013

Emperor penguins walk across sea ice near Ross Island, Antarctica, in this 2012 photo released by Thomas Beer. The continent's pristine habitat provides a laboratory for scientists studying the effects of climate change.

Courtesy Thomas Beer/AP/File

Enlarge

A reconstruction of 2,000 years of global temperatures shows that a long-term decline in Earth's temperatures ended abruptly about 1900, replaced by a warming trend that has continued despite the persistence into the 20th century of the factors driving the cooling, according to a new study.

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Indeed, for several continents, the increase in global average temperatures from the 19th century to the 20th was the highest century-to-century increase during the 2,000-year span, the study indicates. It's the first study to attempt building a millennial-scale climate history, continent by continent.

The research wasn't designed to identify the cause of the warming trend, which climate researchers say has been triggered by a buildup of greenhouse gases ? mainly carbon dioxide ? as humans burned increasing amounts of fossil fuel and altered the landscape in ways that released CO2.

Still, it's hard to explain 20th-century warming without including the influence of rising CO2 levels, because the factors driving the cooling were still present, notes Darrell Kaufman, a researcher at Northern Arizona University and one of the lead authors on the paper formally reporting the results in the journal Nature Geoscience.

The study, five years in the making, drew on the work of 87 scientists in 24 countries as part of the International Geosphere-Biosphere Program. One goal of the 27-year-old program is to gain a deeper understanding of Earth's climate history and the factors that contribute to climate variability.

The study used nature's proxies for thermometers ? tree rings, pollen, and other natural temperature indicators ? to build continent by continent a coordinated record of temperature changes during the past two millenniums.

Scientists use this proxy approach to reach further into the climate's temperature history than the relatively short thermometer record allows. Such efforts aim to put today's climate into a deeper historical context as well as to identify the duration and possible triggers for natural swings that the climate undergoes over a variety of time scales.

Last March, for instance, a team led by Shaun Marcott at Oregon State University used climate proxies to build a global temperature record reaching back 1,200 years ? one that also noted the pre-1900 cooling trend.

Until now, however, the proxy approach has been used to reconstruct changes in global-average and hemisphere-wide temperatures, Dr. Kaufman explains.

"There was very little information about past climate variability at the regional scale," he says. Yet the team notes that no one lives in a global-average world. People live in specific regions where geography plays a vital role in shaping the climate patterns they experience.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/s_CQlowEYIE/Earth-s-cooling-came-to-sudden-halt-in-1900-study-shows

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Alleged 9/11 airplane part to be examined

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Twitter reportedly working on location-based discovery tool

The next big Twitter feature? Finding out what your neighbor's talking about, 140 characters at a time, of course. According to All Things D, the service is working on exactly that, a location-based feature that was reportedly developed at a hack week held by the company earlier this month. Twitter, predictably, isn't commenting on the reportedly upcoming feature, but D has says that this information is coming from "multiple sources." No word on how close they all are to one another.

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Fuel barges explode, causing large fire in Ala.

A massive explosion at 3 a.m. EDT on one of the two barges still ablaze in the Mobile River in Mobile, Ala., on Thursday, April 25, 2013. Three people were injured in the blast. Fire officials have pulled units back from fighting the fire due to the explosions and no immediate threat to lives. (AP Photo John David Mercer) Three people were hospitalized with burns. Information on their conditions was not immediately available.

A massive explosion at 3 a.m. EDT on one of the two barges still ablaze in the Mobile River in Mobile, Ala., on Thursday, April 25, 2013. Three people were injured in the blast. Fire officials have pulled units back from fighting the fire due to the explosions and no immediate threat to lives. (AP Photo John David Mercer) Three people were hospitalized with burns. Information on their conditions was not immediately available.

A massive explosion at 3a.m. EDT on one of the two barges still ablaze in the Mobile River in Mobile, Ala., on Thursday, April 25, 2013. Three people were injured in the blast. Fire officials have pulled units back from fighting the fire due to the explosions and no immediate threat to lives. (AP Photo John David Mercer) Three people were hospitalized with burns. Information on their conditions was not immediately available.

Fire burns aboard two fuel barges along Mobile River after explosions sent three workers to the hospital. Fire officials have pulled units back from fighting the fire due to the explosions and no immediate threat to lives. (AP Photo/Press Register, Glenn Baeske)

A massive explosion at 3 a.m. EDT on one of the two barges still ablaze in the Mobile River in Mobile, Ala., on Thursday, April 25, 2013. Three people were injured in the blast. Fire officials have pulled units back from fighting the fire due to the explosions and no immediate threat to lives. (AP Photo John David Mercer) Three people were hospitalized with burns. Information on their conditions was not immediately available.

Fire burns aboard two fuel barges along the Mobile River after explosions sent three workers to the hospital Wednesday April 24, 2013. Fire officials have pulled units back from fighting the fire due to the explosions and no immediate threat to lives. (AP Photo John David Mercer)

MOBILE, Ala. (AP) ? A large fire that began with explosions aboard two fuel barges in Mobile, Ala., was rocked by a seventh explosion early Thursday and fire officials said they planned to let the fire, which has injured three, burn overnight.

Firefighters from Mobile and U.S. Coast Guard officials responded after 8:30 p.m. CDT Wednesday to a pair of explosions involving the gas barges in an area of the Mobile River east of downtown, authorities said.

As they were responding, a third explosion occurred around 9:30 p.m., Mobile Fire and Rescue spokesman Steve Huffman wrote in an email to The Associated Press. Additional explosions followed over the next few hours.

The Coast Guard said early Thursday that a one-nautical-mile safety zone had been established around one barge, which it said was "at the dock for cleaning."

Authorities said three people were transported to University of South Alabama Medical Center after suffering burn-related injuries. Huffman identified them as workers with Oil Recovery Co. The three were in critical condition early Thursday, according to hospital nursing administrator Danny Whatley.

Across the river, the Carnival Triumph, the cruise ship that became disabled in the Gulf of Mexico last February before it was towed to Mobile's port, was evacuated, said Alan Waugh, who lives at the Fort Conde Inn in downtown Mobile, across the river from the scene of the explosions. Waugh saw the blasts and said throngs of Carnival employees and others were clustered on streets leading toward the river as authorities evacuated the shipyard.

"It literally sounded like bombs going off around. The sky just lit up in orange and red," he said, "We could smell something in the air, we didn't know if it was gas or smoke." Waugh said he could feel the heat from the explosion and when he came back inside, his partner noticed he had what appeared to be black soot on his face.

U.S. Coast Guard Petty Officer Carlos Vega said the initial blast took place in a ship channel near the George C. Wallace Tunnel ? which carries traffic from Interstate 10 under the Mobile River. The river runs south past Mobile and into Mobile Bay, which in turn flows into the Gulf of Mexico.

Video from WALA-TV (http://bit.ly/15NEYJl) showed flames engulfing a large section of the barge, and a video that a bystander sent to AL.com (http://bit.ly/13vWz4G) showed the fiery explosions and billowing smoke over the river.

The cause of the explosion was not immediately clear, Huffman and Vega said.

"Once (the fire) is out and safe, a full investigation will take place," Huffman wrote.

Mobile Fire Chief Steve Dean told AL.com he was confident the fire wouldn't spread to nearby industrial properties, including the shipyard where the Carnival cruise ship is docked.

Huffman said the ship is directly across the river from the incident ? about two football fields in length.

The barges are owned by Houston-based Kirby Inland Marine, company spokesman Greg Beuerman said. He said the barges were empty and being cleaned at the Oil Recovery Co. facility when the incident began. He said the barges had been carrying a liquid called natural gasoline ? which he said is neither liquefied natural gas or natural gas. He said the company has dispatched a team to work with investigators to determine what caused the fire.

The explosion comes two months after the 900-foot-long Carnival Triumph was towed to Mobile after becoming disabled on the Gulf during a cruise by an engine room fire, leaving thousands of passengers to endure cold food, unsanitary conditions and power outages for several days. The ship is still undergoing repairs there, with many workers living on board.

Carnival didn't immediately respond to an emailed request for comment late Wednesday.

Earlier this month, the cruise ship was dislodged from its mooring by a windstorm that also caused, in a separate incident, two shipyard workers to fall into Mobile Bay. While one worker was rescued, the other's body was pulled from the water more than a week later.

___

Associated Press writer Phillip Lucas in Atlanta contributed to this report.

Associated Press

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Pitt team finds melatonin delays ALS symptom onset and death in mice

Public release date: 25-Apr-2013
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Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences

Melatonin injections delayed symptom onset and reduced mortality in a mouse model of the neurodegenerative condition amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, according to a new study by researchers at the University of Pittsburgh School of Medicine. In a report published online ahead of print in the journal Neurobiology of Disease, the team revealed that receptors for melatonin are found in the nerve cells, a finding that could launch novel therapeutic approaches.

Annually about 5,000 people are diagnosed with ALS, which is characterized by progressive muscle weakness and eventual death due to the failure of respiratory muscles, said senior investigator Robert Friedlander, M.D., UPMC Endowed Professor of neurosurgery and neurobiology and chair, Department of Neurological Surgery, Pitt School of Medicine. But the causes of the condition are not well understood, thwarting development of a cure or even effective treatments.

Melatonin is a naturally occurring hormone that is best known for its role in sleep regulation. After screening more than a thousand FDA-approved drugs several years ago, the research team determined that melatonin is a powerful antioxidant that blocks the release of enzymes that activate apoptosis, or programmed cell death.

"Our experiments show for the first time that a lack of melatonin and melatonin receptor 1, or MT1, is associated with the progression of ALS," Dr. Friedlander said. "We saw similar results in a Huntington's disease model in an earlier project, suggesting similar biochemical pathways are disrupted in these challenging neurologic diseases."

Hoping to stop neuron death in ALS just as they did in Huntington's, the research team treated mice bred to have an ALS-like disease with injections of melatonin or with a placebo. Compared to untreated animals, the melatonin group developed symptoms later, survived longer, and had less degeneration of motor neurons in the spinal cord.

"Much more work has to be done to unravel these mechanisms before human trials of melatonin or a drug akin to it can be conducted to determine its usefulness as an ALS treatment," Dr. Friedlander said. "I suspect that a combination of agents that act on these pathways will be needed to make headway with this devastating disease."

###

Co-authors of the paper include other scientists from the University of Pittsburgh School of Medicine; Harvard Medical School; Ohio State University; Weifang Medical University; Bedford VA Medical System, Boston; St. Joseph's Hospital and Medical Center, Phoenix; University of Texas Medical School at Houston; and VA Pittsburgh Health Care System.

The project was funded by grants NS051756, NS039324, and NS055072 of the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health; the U.S. Department of Defense; and the Muscular Dystrophy Association.

About the University of Pittsburgh School of Medicine

As one of the nation's leading academic centers for biomedical research, the University of Pittsburgh School of Medicine integrates advanced technology with basic science across a broad range of disciplines in a continuous quest to harness the power of new knowledge and improve the human condition. Driven mainly by the School of Medicine and its affiliates, Pitt has ranked among the top 10 recipients of funding from the National Institutes of Health since 1998. In rankings recently released by the National Science Foundation, Pitt ranked fifth among all American universities in total federal science and engineering research and development support.

Likewise, the School of Medicine is equally committed to advancing the quality and strength of its medical and graduate education programs, for which it is recognized as an innovative leader, and to training highly skilled, compassionate clinicians and creative scientists well-equipped to engage in world-class research. The School of Medicine is the academic partner of UPMC, which has collaborated with the University to raise the standard of medical excellence in Pittsburgh and to position health care as a driving force behind the region's economy. For more information about the School of Medicine, see http://www.medschool.pitt.edu.

---

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Public release date: 25-Apr-2013
[ | E-mail | Share ]

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences

Melatonin injections delayed symptom onset and reduced mortality in a mouse model of the neurodegenerative condition amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, according to a new study by researchers at the University of Pittsburgh School of Medicine. In a report published online ahead of print in the journal Neurobiology of Disease, the team revealed that receptors for melatonin are found in the nerve cells, a finding that could launch novel therapeutic approaches.

Annually about 5,000 people are diagnosed with ALS, which is characterized by progressive muscle weakness and eventual death due to the failure of respiratory muscles, said senior investigator Robert Friedlander, M.D., UPMC Endowed Professor of neurosurgery and neurobiology and chair, Department of Neurological Surgery, Pitt School of Medicine. But the causes of the condition are not well understood, thwarting development of a cure or even effective treatments.

Melatonin is a naturally occurring hormone that is best known for its role in sleep regulation. After screening more than a thousand FDA-approved drugs several years ago, the research team determined that melatonin is a powerful antioxidant that blocks the release of enzymes that activate apoptosis, or programmed cell death.

"Our experiments show for the first time that a lack of melatonin and melatonin receptor 1, or MT1, is associated with the progression of ALS," Dr. Friedlander said. "We saw similar results in a Huntington's disease model in an earlier project, suggesting similar biochemical pathways are disrupted in these challenging neurologic diseases."

Hoping to stop neuron death in ALS just as they did in Huntington's, the research team treated mice bred to have an ALS-like disease with injections of melatonin or with a placebo. Compared to untreated animals, the melatonin group developed symptoms later, survived longer, and had less degeneration of motor neurons in the spinal cord.

"Much more work has to be done to unravel these mechanisms before human trials of melatonin or a drug akin to it can be conducted to determine its usefulness as an ALS treatment," Dr. Friedlander said. "I suspect that a combination of agents that act on these pathways will be needed to make headway with this devastating disease."

###

Co-authors of the paper include other scientists from the University of Pittsburgh School of Medicine; Harvard Medical School; Ohio State University; Weifang Medical University; Bedford VA Medical System, Boston; St. Joseph's Hospital and Medical Center, Phoenix; University of Texas Medical School at Houston; and VA Pittsburgh Health Care System.

The project was funded by grants NS051756, NS039324, and NS055072 of the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health; the U.S. Department of Defense; and the Muscular Dystrophy Association.

About the University of Pittsburgh School of Medicine

As one of the nation's leading academic centers for biomedical research, the University of Pittsburgh School of Medicine integrates advanced technology with basic science across a broad range of disciplines in a continuous quest to harness the power of new knowledge and improve the human condition. Driven mainly by the School of Medicine and its affiliates, Pitt has ranked among the top 10 recipients of funding from the National Institutes of Health since 1998. In rankings recently released by the National Science Foundation, Pitt ranked fifth among all American universities in total federal science and engineering research and development support.

Likewise, the School of Medicine is equally committed to advancing the quality and strength of its medical and graduate education programs, for which it is recognized as an innovative leader, and to training highly skilled, compassionate clinicians and creative scientists well-equipped to engage in world-class research. The School of Medicine is the academic partner of UPMC, which has collaborated with the University to raise the standard of medical excellence in Pittsburgh and to position health care as a driving force behind the region's economy. For more information about the School of Medicine, see http://www.medschool.pitt.edu.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-04/uops-ptf042413.php

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Tyler, The Creator 'Totally Does Not Understand' Earl Sweatshirt's Mom

'For some reason she thinks I'm a bad influence on her kid, but he's doing pretty good now,' Odd Future MC says in new #CRWN interview series.
By Rob Markman

Tyler, The Creator
Photo: Roger Kisby/ Getty Images

Source: http://www.mtv.com/news/articles/1706252/tyler-creator-earl-sweatshirt-mom.jhtml

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Egypt proceeds with judiciary law despite uproar

CAIRO (AP) ? Egypt's Islamist-led parliament on Wednesday pushed ahead with a law that could force into retirement many of the nation's most senior judges, despite an uproar by the judiciary over fears the president's allies want to control the courts.

The country's Judges' Club, an organization representing Egypt's judges, warned they would not recognize the law or even the discussions in parliament about it. They vowed to turn to international organizations, such as the United Nations and African Union, to investigate what they said are violations against the judiciary.

More than 6,000 judges from around the country gathered in Cairo Wednesday to decide on a strategy in their power struggle with President Mohammed Morsi.

The crisis over the judiciary is a reflection of the deep polarization that has split the country.

The judiciary, with mostly secular-minded professional judges, is seen by many Egyptians as the one of the only remaining buffers against Islamists' monopoly on power following the ouster of authoritarian ruler Hosni Mubarak in 2011. Since then, Islamist parties have swept elections and dominated legislative councils and the presidency.

President Mohammed Morsi's Muslim Brotherhood party counters that many judges are holdovers from the Mubarak era who must be replaced. Morsi's supporters engaged in violent street clashes last Friday with opponents over calls to "cleanse the judiciary."

In an escalation of the crisis, the legislative committee of the upper house of parliament voted in favor of three draft laws on the judiciary proposed by Islamist groups. It opened the floor for further debate.

One, proposed by Morsi's Freedom and Justice party, the political arm of the Muslim Brotherhood, drops the retirement age for judges from 70 to 60, which would affect nearly a quarter of Egypt's 13,000 judges and prosecution officials.

The draft also would forbid the courts from reviewing or overturning presidential decrees issued by Morsi late last year, including his appointment of a new top prosecutor. The prosecutor remains in place despite a court order last month annulling his appointment.

The opposition vowed to step up its campaign against the bill. Activist groups who helped topple Mubarak, such as the April 6 Movement, are demanding reform of the judiciary and support its independence. April 6 warned in a statement against replacing remnants of Mubarak's regime with Morsi's loyalists.

The head of the criminal court in Cairo's sister city of Giza, Fahmy Munir, was among those at the Judges' Club meeting.

"We tell them, don't transgress against the judiciary," he warned the government, adding that violations against the judiciary are akin to "a challenge to the people."

Presidential spokesman Ihab Fahmy told reporters Wednesday that the Islamist president respects the judges.

"The president wants to contain the judiciary crisis," he said. "The president firmly stressed that it's unacceptable to hurt or encroach on the judiciary."

Among the setbacks the judiciary dealt the president's backers was disbanding the Islamist-dominated parliament last year, citing unconstitutionality of the election law. Last month, the courts challenged a law governing parliamentary elections that were supposed to begin this month, delaying the vote indefinitely. The president's party was pushing for early elections.

The proposal in parliament by the president's party also calls for punishments for judges who refuse their duty to oversee polling stations. Last year, during the vote over a contentious draft of the country's new constitution that was written by Morsi's allies, many judges boycotted the vote to protest a decree that temporarily granted Morsi's decisions immunity from judicial review.

The head of the Judges' Club, Ahmed el-Zind, said they would not go on strike as many did last year, but they would seek international help.

During the parliamentary session, independent lawmaker Tharwat Nafaa ripped up a letter sent by the Judges' Club. The letter demanded the parliament stop debating the law because it said the constitutionality of the body was in dispute.

Before thousands of judges late Wednesday, union chief el-Zind questioned Nafaa's political affiliation. "Are you really independent?" he shouted during his lengthy speech.

The crisis over the judiciary also has prompted the resignations of top Morsi aides.

On Monday, the Morsi's top legal adviser, Mohammed Fouad Gadallah, resigned, saying he wanted to shed light "on the extent of the danger facing the country" at a time when "personal interests are overwhelming national interests."

Two days earlier, Justice Minister Ahmed Mekki submitted his resignation. He was a pro-reform judge under Mubarak before becoming a minister in Morsi's Cabinet. He was criticized by liberals for continuing to serve under Morsi, while Islamists chided him for not supporting the disputed bill.

___

AP writer Sarah El Deeb contributed to this report.

Source: http://news.yahoo.com/egypt-proceeds-judiciary-law-despite-uproar-200547997.html

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Senator Comes Out as State OKs Gay Marriage (ABC News)

Share With Friends: | | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/301091129?client_source=feed&format=rss

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NYC proposes raising age for cigarette purchases

NEW YORK (AP) ? After years of striving to set a national agenda for curbing smoking, New York City may set a new bar. Officials are proposing to make it the most populous place in America to raise the minimum age for buying cigarettes to 21.

City Council Speaker Christine Quinn unveiled a proposal Monday to increase the threshold from 18. That's the federal minimum.

Four states and some communities have raised the age to 19. At least two towns have agreed to raise it to 21.

Quinn says the measure aims to stop young people from developing a potentially deadly habit. Officials say 80 percent of the city's adult smokers started before they were 21.

A retailers' group and a smokers' rights advocate are questioning the effectiveness and fairness of the proposal.

Source: http://news.yahoo.com/nyc-proposes-raising-age-cigarette-purchases-152353491.html

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Huawei sees enterprise sales rising to $10 billion by 2017

HONG KONG (Reuters) - Huawei Technologies Co Ltd, the world's No.2 telecoms equipment maker, expects its networking equipment sales targeted at enterprises to rise to $10 billion by 2017, lower than an earlier target.

"If we can achieve $10 billion sales by 2017, that will be good enough for me," Eric Xu, Huawei executive vice president and one of its rotating CEOs, told an analyst conference in Shenzhen, China, where it is headquartered.

Huawei executives said last year that the company had set a target for enterprise sales of $15 billion by 2017.

Huawei generates revenue mainly from three business groups. Its flagship carrier business sells equipment to telecom operators, while its consumer group sells handsets and tablets to end-users.

Its enterprise unit sells network gear to companies and corporations. Last year, the enterprise unit garnered sales of 11.5 billion yuan ($1.9 billion).

Xu also said on Tuesday that the company expects its IT business to generate between $800 million and $1 billion in revenue this year.

(Reporting by Yimou Lee and Lee Chyen Yee; Editing by Edmund Klamann)

Source: http://news.yahoo.com/huawei-sees-enterprise-sales-rising-10-billion-2017-042421703--finance.html

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Napolitano: Immigration bill makes America more secure (cbsnews)

Share With Friends: | | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/301048986?client_source=feed&format=rss

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Watch Levi Sherwood "Shaolin" Backflip His Motorcycle At 1000 FPS

Levi Sherwood is a professional freestyle motocrosser that hails from New Zealand. He's also the reigning Red Bull X-Fighters champion, which is a freestyle motocross competition that sees these guys flipping and jumping and, generally speaking, doing really crazy shit on their bikes for people all over the world. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/uq7iom8DDT4/watch-levi-sherwood-shaolin-backflip-his-motorcycle-at-1000-fps

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WANTED TO BUY PROPERTIES IN FLORIDA! - Zillow Real Estate ...

Thank you for the request.? We purchase directly from County Auctions in order to get the best pricing, rehab and put them back on the market.? We may consider wholesaling some of these property if you are interested.? This was you get the lowest price and move in condition properties.

Due to inventory shortages on the listed properties, we have to get creative.?

I'll contact you to discuss on Monday.

Source: http://www.zillow.com/advice-thread/WANTED-TO-BUY-PROPERTIES-IN-FLORIDA/488880/

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More Than a Pipe Dream

Texas Gulf Coast activist Hilton Kelley (hat, middle) and Bill McKibben lead an estimated 40,000 marchers for the Forward on Climate rally on Feb 17, 2013.

Courtesy of Christine Irvine/Project Survival Media

It is perhaps fitting that Bill McKibben was among the first people arrested protesting climate change. After all, he had written The End of Nature, the first widely read book on the subject in 1989. At the time, though, he naively thought, as he often puts it now, that people would ?read my book, then change.? But after 10 years of complete governmental inaction, McKibben was ready to try a different tack. And so, on April 21, 2000?a day before Earth Day?he joined a small group of campaign-finance activists in the Capitol Rotunda, where they were arrested with a banner that read, ?Stop campaign contributions from global warmers.?

?That didn't accomplish much,? he said, thinking back on it now. ?It was maybe premature.?

McKibben should know. He has spent the better part of the next decade building a climate movement that in February showed up 50,000 strong on the National Mall in Washington, D.C. Days earlier he had been arrested again, his third and most recent such offense?but this time he was joined by representatives of the nation's largest environmental groups. Robert F. Kennedy Jr. of the Natural Resources Defense Council was there, as were the heads of Greenpeace and Friends of the Earth. But of particular significance was the presence of Sierra Club Executive Director Michael Brune?who broke with the organization's 120-year ban on civil disobedience by cuffing himself to the White House gate.

The occasion was not to stop something as extensive as campaign contributions but rather a single pipeline?the Keystone XL?which, if granted a special presidential permit, would carry dirty oil from Canada's tar sands region in Northern Alberta to the Texas Gulf Coast. McKibben and a few organizers, who now work for his climate group 350.org, had made this pipeline a national issue in August 2011 when they held two weeks of sit-ins in front of the White House. This protest, which led to 1,253 arrests, was the largest organized act of civil disobedience in the United States in decades. [Full disclosure: I was one of those arrested.]

Still, many consider the construction of the Keystone pipeline inevitable?after all, even 54 percent of Democrats support it. It's for this reason that critics such as New York Times columnist Joe Nocera have called the protests ?boneheaded.? They believe environmental action could be better spent on some other goal, like perhaps encouraging people to reduce their carbon footprint.

But these critics are missing something vital about the anti-Keystone movement: It was never about just a pipeline. McKibben and a handful of others had another, less talked about goal?to remake the environmental movement into something far more active, creative, and formidable for years to come. The gap that once existed between mainstream environmental groups and grass-roots activists has now largely dissolved, resulting in widespread action that has not been seen in the United States for decades?perhaps even since the first Earth Day in April 1970.

On that day, mainstream environmental groups with roots going back to the conservation movement of the early 20th century united with grass-roots activists for a day of teach-ins, influenced by the burgeoning student anti-war movement. Amid the thousands of demonstrations that took place across the nation, there was at least one major act of civil disobedience, in which 15 people were arrested for holding a mock funeral inside Boston?s Logan Airport. Interestingly enough, it was a sort of proto-climate protest against a supersonic plane and its accompanying release of water vapor?a major greenhouse gas.

After that Earth Day, however, the two strands of environmentalism largely went their separate ways, with mainstream groups preferring a more professional approach that took them to courtrooms, shareholder meetings, and the halls of Congress rather than street demonstrations. And for a time, that approach succeeded wildly, earning some of the most important and long-standing environmental gains in this country's history. But according to a 2012 report by the National Committee for Responsive Philanthropy, such efforts have yielded no "significant policy changes at the federal level in the United States since the 1980s." For perhaps no issue is that fact more clear than with climate change.

?We knew enough way back then to act,? says James Gustave Speth, who has advised two presidents on the environment and co-founded the Natural Resources Defense Council in 1970. ?When I was chair of President Carter's Council on Environmental Policy, we issued several reports calling for climate action. So much for my effectiveness.?

Speth has since turned to activism and was among the first people arrested during the two weeks of sit-ins outside the White House.

Source: http://feeds.slate.com/click.phdo?i=8a2d0e17667e6e04eccfb08abf14d1a5

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'Boston Strong' emerges as rallying cry, from stadiums to tweets

In the week since the Boston Marathon bombing, a new phrase, "Boston Strong," has sprung up around the country as sports fans put aside their rivalries and reach out to a city in pain. NBC's Luke Russert reports.

By Lou Dubois, NBC News

Amid a week of terror in Boston, one common theme of support emerged online and off, locally, across America and around the world: "Boston Strong."

"We are one. We are strong. We are Boston. We are Boston strong," the Red Sox public address announcer said to an eruption of cheers?Saturday, as the city came together at the first home game following the tragic events. The crowd honored the fallen and celebrated the heroic, and some, such as slugger David Ortiz, spoke their minds.

That followed a new tradition in the city that?started on Wednesday?at the Boston Bruins hockey game, with the crowd in each stadium singing the "Star Spangled Banner" loudly and in unison.

Online, #BostonStrong was a trending topic on Twitter for much of the week and has been mentioned nearly half a million times since Monday.

Google

"Boston Strong" images flooded the Internet over the past few days, as this image search reveals.

Facebook pages, updated profile photos, ribbons and much more are just the beginning of the wide digital reach of the two words. Even the famed "Green Monster" at Fenway Park was?outfitted with a "Boston Strong" insignia?by the Red Sox, an announcement the team made via its official Twitter feed.

"I think it's been viewed as an extraordinarily generous gesture," said journalist Mike Barnicle, a Massachusetts native and MSNBC contributor. "I think it's put an all new light on the relationship between cities?... Cities get down after terrorist attacks ? they're momentarily shocked and angry, but they get up, they continue and the people who live in and around those cities get up and continue because that's who we are."

Around the nation and around the world, the two words have taken on a meaning of their own. From a special?"Boston Strong" run in San Diego?to a moment of silence and remembrance?before Sunday's London Marathon?to a?Milwaukee T-shirt shop?printing shirts selling rapidly around, it's a movement that shows real unity and seems to know no bounds.

Nick Reynolds and Chris Dobens, Emerson College students in Boston who started an online campaign to sell "Boston Strong" T-shirts to raise money for The One Fund Boston, have already received?over 23,000 orders.

"Boston is a tough and resilient town, so are its people," President Barack Obama said in a speech Monday following the bombings. "I'm supremely confident that Bostonians will pull together, take care of each other, and move forward as one proud city and as they do, the American people will be with them every single step of the way."

"This is Boston," Mayor Tom Menino said Wednesday at an interfaith service, "a city with courage, compassion and strength that knows no bounds."

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2b01e4c3/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A40C210C17850A3750Eboston0Estrong0Eemerges0Eas0Erallying0Ecry0Efrom0Estadiums0Eto0Etweets0Dlite/story01.htm

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NASA successfully launches three smartphone satellites

Apr. 22, 2013 ? Three smartphones destined to become low-cost satellites rode to space Sunday aboard the maiden flight of Orbital Science Corp.'s Antares rocket from NASA's Wallops Island Flight Facility in Virginia.

The trio of "PhoneSats" is operating in orbit, and may prove to be the lowest-cost satellites ever flown in space. The goal of NASA's PhoneSat mission is to determine whether a consumer-grade smartphone can be used as the main flight avionics of a capable, yet very inexpensive, satellite.

Transmissions from all three PhoneSats have been received at multiple ground stations on Earth, indicating they are operating normally. The PhoneSat team at the Ames Research Center in Moffett Field, Calif., will continue to monitor the satellites in the coming days. The satellites are expected to remain in orbit for as long as two weeks.

"It's always great to see a space technology mission make it to orbit -- the high frontier is the ultimate testing ground for new and innovative space technologies of the future," said Michael Gazarik, NASA's associate administrator for space technology in Washington.

"Smartphones offer a wealth of potential capabilities for flying small, low-cost, powerful satellites for atmospheric or Earth science, communications, or other space-born applications. They also may open space to a whole new generation of commercial, academic and citizen-space users."

Satellites consisting mainly of the smartphones will send information about their health via radio back to Earth in an effort to demonstrate they can work as satellites in space. The spacecraft also will attempt to take pictures of Earth using their cameras. Amateur radio operators around the world can participate in the mission by monitoring transmissions and retrieving image data from the three satellites. Large images will be transmitted in small chunks and will be reconstructed through a distributed ground station network. More information can found at: http://www.phonesat.org

NASA's off-the-shelf PhoneSats already have many of the systems needed for a satellite, including fast processors, versatile operating systems, multiple miniature sensors, high-resolution cameras, GPS receivers and several radios.

NASA engineers kept the total cost of the components for the three prototype satellites in the PhoneSat project between $3,500 and $7,000 by using primarily commercial hardware and keeping the design and mission objectives to a minimum. The hardware for this mission is the Google-HTC Nexus One smartphone running the Android operating system.

NASA added items a satellite needs that the smartphones do not have -- a larger, external lithium-ion battery bank and a more powerful radio for messages it sends from space. The smartphone's ability to send and receive calls and text messages has been disabled. Each smartphone is housed in a standard cubesat structure, measuring about 4 inches square. The smartphone acts as the satellite's onboard computer. Its sensors are used for attitude determination and its camera for Earth observation.

For more about information about NASA's Small Spacecraft Technology Program and the PhoneSat mission, visit: http://www.nasa.gov/smallsats

The PhoneSat mission is a technology demonstration project developed through the agency's Small Spacecraft Technology Program, part of NASA's Space Technology Mission Directorate. The directorate is innovating, developing, testing and flying hardware for use in future science and exploration missions. NASA's technology investments provide cutting-edge solutions for our nation's future. For more information about NASA's Space Technology Mission Directorate, visit: http://www.nasa.gov/spacetech

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The above story is reprinted from materials provided by NASA.

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Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/space_time/nasa/~3/Lx8EU3pdzsI/130422112914.htm

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